Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance.

PROPOSTA: O objetivo deste estudo foi realizar uma análise crítica da literatura considerando as manifestações bucais, esqueléticas e de desenvolvimento associadas à anemia de Fanconi (AF) e apresentar um caso clínico. DESCRIÇÃO DO CASO: Trata-se de um paciente branco, sexo masculino, de 18 anos de idade, com aparência de uma criança de aproximadamente 12 anos de idade. Ao exame bucal observaram-se lesões de cárie, gengivite, mordida cruzada bilateral e mordida aberta anterior. Vários dentes permanentes estavam ausentes e muitos dentes decíduos ainda estavam presentes. CONCLUSÃO: A revisão crítica da literatura revelou um padrão heterogêneo com relação às manifestações bucais da AF, como observado no caso clínico descrito. As manifestações bucais mais comuns da doença são gengivite, periodontite, agenesia dental e carcinoma de células escamosas.

PURPOSE: To present a critical analysis of the dental literature about the oral, skeletal and developmental manifestations associated with Fanconi's anemia (FA) and to describe a clinical case. CASE DESCRIPTION: Patient: male, Caucasian, 18 years-old. At the physical exam, the patient's appearance was roughly that of a 12-year-old child. The oral exam revealed carious lesions, gingivitis, bilateral crossbite and anterior open bite. Several teeth were absent and several primary teeth were present. CONCLUSION: The review of the literature reveals a heterogeneous pattern for the oral manifestations of FA, as observed in the case described in the present report. The most common oral manifestations of the disease are gingivitis, periodontitis, dental agenesis and squamous cell carcinoma.

A transverse study carried out in the years of 1995 and 2000. The aim was to describe a specific population in Diamantina, according to some predisposing high blood pressure factors. The variables studied were: high blood pressure, gender, age, race, smoking and drinking habits. The frequency of high blood pressure in 1995 was of 44,77% and 33,66% in 2000, being higher among men, in black people and increasing as they grow older. High blood pressure was found to be highest in the smoking and/or drinking habits group in 1995. However, in 2000, the highest blood pressure was found among the non-smoking and non-drinking group.

Se trata de un estudio transversal efectuado entre 1995 y 2000con miras a caracterizar una población específica de Diamantina con relación a algunos factores que predisponen para la hipertensión arterial. Se evaluaron las variables hipertensión arterial, sexo, edad, raza, adicción al tabaco y al alcohol. La frecuencia de presión arterial elevada (PAE) en 1995 fue de un 44,77% y en 2000 del 33,66%, mayor entre los hombres, en la raza negra y aumenta con la edad. En cuanto a la adicción al tabaco y/o alcohol, en 1995 los niveles más altos de presión arterial se detectaron en dicho grupo y en 2000 la PAE se manifestó más en individuos no fumadores y no alcohólicos.

Estudo transversal realizado nos anos de 1995 e 2000. Objetivou-se caracterizar uma população específica de Diamantina, em relação a alguns fatores predisponentes para Hipertensão Arterial. As variáveis avaliadas foram: pressão arterial, sexo, idade, raça, tabagismo e etilismo. A freqüência de Pressão Arterial Elevada (PAE) foi em 1995 de 44,77%, e em 2000 de 33,66%, sendo maior entre os homens; na raça negra e crescente com a idade. Em relação ao tabagismo e/ou etilismo, em 1995 os maiores níveis pressóricos foram detectados neste grupo, e em 2000 a PAE foi mais presente nos indivíduos não tabagistas e/ou etilistas